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Liver bioscaffold as a new strategy for liver regeneration: a systematic review
Diseases that lead to hepatic failure continue to grow in the world and liver transplantation is the only curative option for patients with end stage liver disease. Unfortunately, the treatment is severely limited by some issues, including the low availability of donor organs. Recently, liver decellularized scaffolds have been being proposed as a novel strategy to overcome these issues. Many advances have been achieved in the last years, making this technique much more feasible.
Objetivos - Metodologia - Resultados - Discussão dos Resultados/Objectives - Methodology - Results - Discussion of Results/Objetivos - Metodología - Resultados - Discusión de los resultados
This systematic review describes chronologically the progress of this promising technique and highlight future challenges in the field.
We adapted from the rules proposed in the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guide. We search in Scielo (http://www.scielo.org), Pubmed (http://www.ncbi.nlm.nih.gov/pubmed) and Lilacs (http://lilacs.bvsalud.org) databases were searched between December 2017 and April of 2018. An additional manual search using references contained in main selected articles was also performed. A window of ten years without language limitations was used. Searches were performed using the descriptive terms “liver”, “recellularization” and “decellularization” based on the medical terms of the National Library of Medicine (https://meshb.nlm.nih.gov/search). The Boolean expressions “AND” was used in order to find the registries in which “liver” was associated with at least one of the other descriptive terms listed.
Adding all databases, 1238 articles were found. After analyzing article titles, it was observed that some articles were found in more than one database, while others did not fit with the criterion established for this study. In the end, 22 articles were elected for the review.
Considerações Finais/Final considerations/Consideraciones finales
As the result of international efforts, the evolution of this technique in the last few years becomes clear, but the last step (recellularization) needs improvement to be viable in any clinical trial. Such advances made hepatic bioartificial organ much more realistic, with great hopes for future clinical applications, and an immense contribution for medicine. We hope that this technique will continue to develop rapidly, so that we could have it implemented clinically in the near future, in order to generate improvements especially to those patients in line for liver transplant.
Palavras-chave/Key words/Palabras clave
Bioengineering; Biomaterials; Liver; Organ transplantation; Regenerative medicine.
Scaffold (surface topology and softness)
ERIK ARANHA ROSSI, LUIZ FERNANDO QUINTANILHA DE MESQUITA, BRUNO SOLANO SOUZA