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Functional hybrid scaffold PVA-BG containing cobalt as a potential strategy for tissue engineering
Introduction: Tissue Engineering consists of the development and manipulation of molecules, cells, tissues, or organs to replace or assist in the function of defective or damaged body parts. The possibility of developing complex three-dimensional tissues, reproducing the design and function of human tissue is a recent development. The need for alternatives to repair or replace living tissues has generated a search for superior materials. One class of biomaterials studied for use in tissue engineering is hybrid materials. Functional organic-inorganic hybrids are gaining large relevance as materials for Tissue Engineering and Regenerative Medicine. Bioactive glasses (BGs) have a variable and highly flexible composition, allowing the incorporation of metallic ions with therapeutic effect, a propitious approach in the development of BGs with superior properties for tissue engineering. Cobalt (Co) presents great potential for incorporation into the structure of bioactive glasses, since it may influence the formation of new blood vessels.
Objetivos - Metodologia - Resultados - Discussão dos Resultados/Objectives - Methodology - Results - Discussion of Results/Objetivos - Metodología - Resultados - Discusión de los resultados
Objective: The main objective of this work was to synthesize PVA and BG hybrid scaffolds with new compositions in the SiO2-CaO-P2O5-CoO system, by the sol-gel method, and to investigate the effects of Co incorporation on its structure, to obtain angiogenic properties in a material with controlled release capacity of this ion. Methodology: The hybrid scaffolds obtained were subjected to the strict characterization through ICP-OES, FTIR, MicroCT, XRD, SEM and EDS analyzes. Results and Discussion: Hybrid scaffolds with BGs containing 5% and 10% Co were obtained, and the composition was confirmed by chemical analysis (ICP-OES and FTIR). The porous three-dimensional structure was characterized by MicroCT. The porosities and interconnectivities obtained are within values favorable for the cellular environment. XRD analyzes showed amorphous phase with some crystalline peaks compatible with calcium silicate. SEM images showed microporous and macroporous surface corroborating with structural MicroCT results.
Considerações Finais/Final considerations/Consideraciones finales
Final considerations: The results indicate that functional hybrid scaffolds produced with cobalt incorporation into their structure presented favorable properties and it is potential strategies to obtain auxiliary materials for tissue engineering.
Palavras-chave/Key words/Palabras clave
Key words: Bioactive glass, PVA, cobalt, scaffolds, tissue engineering.
ANDREIA GROSSI SANTOS DE LAIA, MARCOS AUGUSTO DE SÁ, MARIVALDA DE MAGALHÃES PEREIRA